Process for the preparation of colored seleniferous and telluriferous substances.



UNITED STATES PATENT OFFICE.

Anensr von WASSERMANN, or BEERLIN, Ann nnivs'r WASSERMANN, or minnow.

' ON-THE-MAIN, GERMANY.

rnocnss FOR THE PREPARATION or cononnn SELENIFEROUS AND ,TEL URI ELQUS SUBSTANCES.

No Drawing.

To all whom it may concern Be it knownthat we, Aucusrvoiv WAS- SERMAN'N, privy medicalcouncillor and uni-- versity professor, and EnivsTYVAssnnMaNN, chemist, citizens of the German Empire, re-

siding at Rauchstrasse 7, Berlin, and Liebig strasse 21*, Frankfort-on-tlie-Main, Germany, have invented certain new and useful Improvements in Processes for the Prepa'ration of Colored Seleniferous and Tel lurit'e'rous. Substances, of which the following is a specification. I

,The present. invention relates to anew or improved process for the preparation of colored seleniferous or when fairly concentrated aqueoussolutions of salts of halogenated dyestuffs of the plithalein series are treated with suitable compounds of selenium or tfelluriuin,precipitates are obtained which consist of new seleniferous or telluriferous compounds respectively. Among the compounds of telluriuni and selenium, the ammonium,

' sodium and potassium. salts of selenoand telluro-cyani'c acid. have proved to be particularly suitable.

The following: example will serve to illus-' cipitate is formed which in' a few hours.

time can be separated from the supernatant liquid. Selenium can easily be detected in the precipitate.

The new substances form excellent dye-- stufls. They can. moreover, be employed for introducing selenium and telluriumintothe animal body, and by this means selenium and tellurium can also'be introduced into parts of the body into which such introduc tion has not so far been possible with the compounds of these substances hitherto known.

tellu'riferous sub-- stances. It is based on the observation that Specif cation of Letters Patent. Patented May13, 1913. Application filed January 24, 1912. Serial No. 673,136.

The productsobtained according to the present invention are less poisonous than the raw substances from which they are preparedfThese products are very unstable combinations or so-called'adsorption's which very easily split off the selenium; They are characterized mainly by their biologic efliciency. For example, they-have,.when introduced into the blood circulation ofwhite mice, the ability of coloring red swellings.

or tumors. Heretofore, that property has not been possessed by any other dye or color. For instance, the raw substance; such for'example as sodiumsalt of eosin,

does-not possess this property.

F \Vhat we claim is 1. Process for the preparation of seleniferous and telluriferous colored substances,w'hich consists in allowing, salts of halogenated dye-stufi's of the iphthal'ein seriesto re-aet. with suitable compounds of.sele-- nium or telluriuni. v I

2. Process for the preparation. of seleniferous colored substances, which consists in allowing salts of halogenated dyestufi's of the phthalein series to re-act with alkali salts of the seleno' cyanicacid or telluro c'yani'c acid, and in separating the so formed precipitate from the supernatant liquid;

3. As new articles of manufacture.colored compounds of the halogenated dyestuffs of the phtlialein series c ontai ning selenium having a very dark color when dry and in the form of a powder, and. being more readily soluble in water than the raw material, having an intensive blood red color when so dissolved.

In testimony whereof we have hereunto.

set our'hands'in presence of two subscribing witnesses."

neusrms *ASSERMANN. ERNST :WASSEBMANN.

\Vitnesses: I Hnxiiy HASTER, "Womni im HAUPT. 

